What molecule, in free form, is secreted at concentrations of about 50 μM in saliva?

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Multiple Choice

What molecule, in free form, is secreted at concentrations of about 50 μM in saliva?

Explanation:
Free amino acids in saliva can contribute to buffering the oral environment and supporting mucosal health. Histidine stands out because its side chain, the imidazole group, has a pKa near physiological pH. That lets the imidazole ring accept or donate protons around the pH of saliva, providing effective buffering as acids are produced by oral bacteria. At about 50 μM in saliva, histidine can meaningfully contribute to maintaining a stable pH in the mouth. The other amino acids listed can be present in saliva, but they don’t typically sit at this buffering-relevant free concentration, and their properties don’t give the same buffering capability at physiological pH.

Free amino acids in saliva can contribute to buffering the oral environment and supporting mucosal health. Histidine stands out because its side chain, the imidazole group, has a pKa near physiological pH. That lets the imidazole ring accept or donate protons around the pH of saliva, providing effective buffering as acids are produced by oral bacteria. At about 50 μM in saliva, histidine can meaningfully contribute to maintaining a stable pH in the mouth. The other amino acids listed can be present in saliva, but they don’t typically sit at this buffering-relevant free concentration, and their properties don’t give the same buffering capability at physiological pH.

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